Exploring the Intricacies of Cellular Metabolism: Unveiling new mechanisms of disease.
At the core of life lie chemical reactions that we collectively call metabolism. Enzymes drive most of these reactions, organized into pathways that were discovered in the past century. While textbooks imply we've uncovered all cellular metabolic enzymes, reality differs: Enzymes with unknown functions remain, and some enzyme roles have been misinterpreted. Additionally, certain chemical reactions occur without enzymes, yet significantly impacting human health and aging.
Guido Bommer and his team are dedicated to investigating these lesser-known aspects of cellular metabolism, uncovering novel mechanisms behind various human diseases, ranging from cancer to neurodegeneration. Their approach combines mass spectrometry, genetics, and classical enzymology techniques. While their research often starts with a specific idea, projects sometimes take unexpected turns, leading to findings far from the initial hypotheses.
Recently, this has led to the elucidation of the biogenesis of novel post-translational modifications involved in neuromuscular diseases (i.e. ribitolphosphorylation) and Parkinson's disease (i.e. N-glyceroylation and N-phosphoglyceroylation).