1. CELL Projects

  • Donatienne Tyteca: Importance of membrane domains for cell deformability and disease
  • Christophe Pierreux: Intrinsic and extrinsic control of epithelial differentiation
  • Pierre Courtoy: Physiopathology and adaptation mechanisms in kidney and thyroid of cystinosis, a paradigmatic lysosomal storage disorder due to inherited defective lysosomal cystine exporter.
  • Patrick Henriet: Functions and molecular targets of matrix metalloproteinase (MMP)-27
  • Etienne Marbaix: Mechanisms and regulation of endometrium remodeling and regeneration


2. Publications

2018 & in press

  1. Grieco G, Janssens V, Gaide Chevronnay HP, N’Kuli F, Van Der Smissen P, Wang TS, Shan J, Vainio S, Bilanges B, Jouret F, Vanhaesebroeck B, Pierreux CE, Courtoy PJ. Suppression of Vps34 PI 3-kinase activity in kidney proximal tubules abrogates apical trafficking and causes a Fanconi syndrome. Scientific Reports (2018), In press.
  2. Leonard C, Pollet H, Vermylen C, Gov NS, Tyteca D, Mingeot-Leclercq MP. Tuning of differential lipid order between submicrometric domains and surrounding membrane upon erythrocyte reshaping. Cell Physiol Biochem (2018), In press.
  3. Verstraeten SL, Albert M, Paquot A, Muccioli GG, Tyteca D, Mingeot-Leclercq MP. Membrane cholesterol delays cellular apoptosis induced by Ginsenoside Rh2, a steroid saponin. Toxicol Appl Pharmacol. (2018), 352:59-67.
  4. Degosserie J, Heymans C, Spourquet C, Halbout M, Van Der Smissen P, Vertommen D, Courtoy PJ, Tyteca D, Pierreux CE. Extracellular vesicles from endothelial progenitor cells promote thyroid follicle formation. J Extracellular Vesicles (2018), 7(1):1487250.
  5. Demarez C, Gérard C, Cordi S, Poncy A, Achouri Y, Dauguet N, Rosa DA, Gunning PT, Manfroid I, Lemaigre FP. MiR-337-3p controls hepatobiliary gene expression and transcriptional dynamics during hepatic cell differentiation. Hepatology (2018), 67, 313-327.


  1. Milosevic TV, Payen VL, Sonveaux P, Muccioli GG, Tulkens PM, Van Bambeke. Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically-relevant Concentrations in cultured Human HL-60 promyelocytes and THP-1 monocytes. Antimicrob Agents Chemother. (2017), pii: AAC.01599-17.
  2. Leonard C, Conrard L, Guthmann M, Pollet H, Carquin M, Vermylen C, Gailly P, Van Der Smissen P, Mingeot-Leclercq MP, Tyteca D. Contribution of plasma membrane lipid domains to red blood cell (re)shaping. Sci Rep. (2017), 7(1):4264.
  3. Coomans de Brachène A, Dif N, de Rocca Serra A, Bonnineau C, Velghe AI, Larondelle Y, Tyteca D, Demoulin JB. PDGF-induced fibroblast growth requires monounsaturated fatty acid production by stearoyl-CoA desaturase. FEBS Open Bio. (2017), 7(3):414-423.
  4. Bulanova EA, Koudan EV, Degosserie J, Heymans C, Pereira FD, Parfenov VA, Sun Yi, Wang Qi, Akhmedova SA, Sergeeva NS, Frank GA, Khesuani YD, Pierreux CE, Mironov VA. Bioprinting of functional and vascularized mouse thyroid gland construct. Biomaterials (2017), 9:034105.



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