Cells need to adjust their metabolism to fulfill changing needs for building blocks, energy and protection from stress. We search for vulnerabilities in known or newly discovered metabolic pathways that might be targeted in future therapies for variety of diseases ranging from cancer to Parkinson's disease.
We are investigating the role of a series of enzymes, for which we have reason to believe that they might be involved in the synthesis of regulatory molecules. In these studies, we use a combination of state-of-the-art metabolomics (GC-MS and LC-MS) and genetic manipulation of cell lines to understand the cellular effects of novel regulatory molecules. Classical enzymological studies (in collaboration with the laboratory of Emile Van Schaftingen & Maria Veiga-Da-Cunha) on purified proteins are then used to understand the molecular basis of the observed effects. Eventually, we hope that our work will reveal novel therapeutic targets in cancer. Currently, we are particularly interested in several phosphatases that might serve to eliminate metabolic side-products or metabolic regulators.
While we strive to understand processes involved in cancer biology, we remain very much open to surprising discoveries. As such, we have recently discovered a novel post-translational modification of α-dystroglycan by ribitolphosphorylation. Furthermore, we are following-up on observations that suggest that so far unknown biochemical changes may contribute to the development of Parkinson’s disease.
Nat Chem Biol. 2016; 12(8):601-7.
Nat Commun. 2016; 7:11534.
Gerin I, Noël G, Bolsée J, Haumont O, Van Schaftingen E, Bommer GT.
Biochem J. 2014; 458(3):439-48.
Feng Y, Bommer GT, Zhao J, Green M, Sands E, Zhai Y, Brown K, Burberry A, Cho KR, Fearon ER.
Gastroenterology. 2011; 141(3):1003-1013.e1-10.
Bommer GT, MacDougald OA.
Cell Metab. 2011; 13(3):241-7.
Fearon ER, Bommer GT.
Gastroenterology. 2011; 140(4):1139-43.
Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, Leclercq IA, MacDougald OA, Bommer GT.
J Biol Chem. 2010; 285(44):33652-61.
Gerin I, Bommer GT, McCoin CS, Sousa KM, Krishnan V, MacDougald OA.
Am J Physiol Endocrinol Metab. 2010; 299(2):E198-206.
Herbst A, Bommer GT, Kriegl L, Jung A, Behrens A, Csanadi E, Gerhard M, Bolz C, Riesenberg R, Zimmermann W, Dietmaier W, Wolf I, Brabletz T, Göke B, Kolligs FT.
Gastroenterology. 2009; 137(2):639-48, 648.e1-9.
Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE, Zhai Y, Giordano TJ, Qin ZS, Moore BB, MacDougald OA, Cho KR, Fearon ER.
Curr Biol. 2007; 17(15):1298-307.
Metabolism in Cancer & Other Diseases