1. CELL Projects

  • Donatienne Tyteca: Importance of membrane domains for cell deformability and disease
  • Christophe Pierreux: Intrinsic and extrinsic control of epithelial differentiation
  • Pierre Courtoy: Physiopathology and adaptation mechanisms in kidney and thyroid of cystinosis, a paradigmatic lysosomal storage disorder due to inherited defective lysosomal cystine exporter.
  • Patrick Henriet: Functions and molecular targets of matrix metalloproteinase (MMP)-27
  • Etienne Marbaix: Mechanisms and regulation of endometrium remodeling and regeneration


2. Publications


  1. Cloos AS, Daenen LGM, Maja M, Stommen A, Vanderroost J, Van Der Smissen P, Rab M, Westerink J, Mignolet E, Larondelle Y, Terrasi R, Muccioli G, Dumitru AC, Alsteens D, van Wijk R, Tyteca D. Impaired Cytoskeletal and Membrane Biophysical Properties of Acanthocytes in Hypobetalipoproteinemia – A Case Study. Frontiers in Physiology (2021) 12(2):638027.

  2. Dumitru AC, Stommen A, Koehler M, Cloos AS, Yang J, Leclercqz A, Tyteca D, Alsteens D. Probing PIEZO1 Localization upon Activation Using High-Resolution Atomic Force and Confocal Microscopy. Nano Letters (2021) 21(12):4950-4958.


  1. Pollet H, Cloos AS, Stommen A, Vanderroost J, Conrard L, Paquot A, Ghodsi M, Carquin M, Léonard AC, Guthmann M, Lingurski M, Vermylen C, Killian T, Gatto L, Rider MH, Pyr dit Ruys S, Vertommen D, Vikkula M, Brouillard P, Van Der Smissen P, Muccioli G, Tyteca D. Aberrant Membrane Composition and Biophysical Properties Impair Erythrocyte Morphology and Functionality in Elliptocytosis. Biomolecules (2020) 10(8):1120.

  2. Cloos AS, Ghodsi M, Stommen A, Vanderroost J, Dauguet N, Pollet H, D'Auria L, Mignolet E, Larondelle Y, Terrasi R, Muccioli G, Van Der Smissen P, Tyteca D. Interplay Between Plasma Membrane Lipid Alteration, Oxidative Stress and Calcium-Based Mechanism for Extracellular Vesicle Biogenesis From Erythrocytes During Blood Storage.. Frontiers in Physiology (2020) 11:712.
  3. De Groof A, Ducreux J, Vidal-Bralo L, Tyteca D, Galant C, Marot L, Coulie PG, Van den Eynde BJ, Rodriguez-Martinez L, Santos MJ, Suarez A, Carreira P, Marchini M, Gonzàlez A, Houssiau FA, Lauwerys BR. Toll-like receptor 3 increases antigen-presenting cell responses to a pro-apoptotic stimulus, yet does not contribute to systemic lupus erythematosus genetic susceptibility. Clin Exp Rheumatol. (2020) 38(5):881-890.

  4. Demaret T, Courtoy GE, Ravau J, Van Der Smissen P, Najimi M, Sokal EM. Accurate and live peroxisome biogenesis evaluation achieved by lentiviral expression of a green fluorescent protein fused to a peroxisome targeting signal 1. Histochem Cell Biol. (2020) 153(5):295-306.

  5. Le Roy T, Van der Smissen P, Paquot A, Delzenne N, Muccioli GG, Collet JF, Cani PD. Dysosmobacter welbionis gen. nov., sp. nov., isolated from human faeces and emended description of the genus Oscillibacter. . Int J Syst Evol Microbiol. (2020) 70(9):4851-4858.


  1. Vanbever R, Loira-Pastoriza C, Dauguet N, Hérin C, Ibouraadaten S, Vanvarenberg K, Ucakar B, Tyteca D, Huaux F. Cationic Nanoliposomes Are Efficiently Taken up by Alveolar Macrophages but Have Little Access to Dendritic Cells and Interstitial Macrophages in the Normal and CpG-Stimulated Lungs. Mol Pharm. (2019) 16(5):2048-2059.

  2. Pierrot N, Ris L, Stancu IC, Doshina A, Ribeiro F, Tyteca D, Baugé E, Lalloyer F, Malong L, Schakman O, Leroy K, Kienlen-Campard P, Gailly P, Brion JP, Dewachter I, Staels B, Octave JN. Sex-regulated gene dosage effect of PPARα on synaptic plasticity. Life Sci Alliance. (2019) 2(2): pii: e201800262.

  3. Janssens V, Gaide Chevronnay HP, Marie S, Vincent MF, Van Der Smissen P, Nevo N, Vainio S, Nielsen R, Christensen EI, Jouret F, Antignac C, Pierreux CE, Courtoy PJ. Protection of Cystinotic Mice by Kidney-Specific Megalin Ablation Supports an Endocytosis-Based Mechanism for Nephropathic Cystinosis Progression. J Am Soc Nephrol. (2019) 30(11):2177-2190.

  4. Coppin L, Najimi M, Bodart J, Rouchon MS, van der Smissen P, Eeckhoudt S, Dahlqvist G, Castanares-Zapatero D, Komuta M, Brouns SL, Baaten CC, Heemskerk JWM, Horman S, Belmonte N, Sokal E, Stéphenne X. Clinical Protocol to Prevent Thrombogenic Effect of Liver-Derived Mesenchymal Cells for Cell-Based Therapies.  Cells. (2019) 8(8). pii: E846.

  5. Le Roy T, Van der Smissen P, Paquot A, Delzenne N, Muccioli GG, Collet JF, Cani PD. Dysosmobacter welbionis gen. nov., sp. nov., isolated from human faeces and emended description of the genus Oscillibacter. Int J Syst Evol Microbiol. (2019) 69(3):833-83.

  6. Swain J, El Khoury M, Flament A, Dezanet C, Briée F, Van Der Smissen P, Décout JL, Mingeot-Leclercq MP. Antimicrobial activity of amphiphilic neamine derivatives: Understanding the mechanism of action on Gram-positive bacteria. Biochim Biophys Acta Biomembr. (2019) 1861(10):182998.

  7. Le Roy T, Van der Smissen P, Paquot A, Delzenne N, Muccioli GG, Collet JF, Cani PD. Butyricimonas faecalis sp. nov., isolated from human faeces and emended description of the genus Butyricimonas. Int J Syst Evol Microbiol. (2019) 69(3):833-838.


  1. Wiame E, Tahay G, Tyteca D, Vertommen D, Stroobant V, Bommer GT, Van Schaftingen E. NAT6 acetylates the N-terminus of different forms of actin. FEBS J. (2018) 285(17):3299-3316.

  2. Grieco G, Janssens V, Gaide Chevronnay HP, N’Kuli F, Van Der Smissen P, Wang TS, Shan J, Vainio S, Bilanges B, Jouret F, Vanhaesebroeck B, Pierreux CE, Courtoy PJ. Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency. Scientific Reports (2018) 8(1):14133.

  3. Leonard C, Pollet H, Vermylen C, Gov NS, Tyteca D, Mingeot-Leclercq MP. Tuning of differential lipid order between submicrometric domains and surrounding membrane upon erythrocyte reshaping. Cell Physiol Biochem (2018) 48(6):2563-2582.

  4. Verstraeten SL, Albert M, Paquot A, Muccioli GG, Tyteca D, Mingeot-Leclercq MP. Membrane cholesterol delays cellular apoptosis induced by Ginsenoside Rh2, a steroid saponin. Toxicol Appl Pharmacol. (2018) 352:59-67.

  5. Degosserie J, Heymans C, Spourquet C, Halbout M, Van Der Smissen P, Vertommen D, Courtoy PJ, Tyteca D, Pierreux CE. Extracellular vesicles from endothelial progenitor cells promote thyroid follicle formation. J Extracellular Vesicles (2018) 7(1):1487250.

  6. Demarez C, Gérard C, Cordi S, Poncy A, Achouri Y, Dauguet N, Rosa DA, Gunning PT, Manfroid I, Lemaigre FP. MiR-337-3p controls hepatobiliary gene expression and transcriptional dynamics during hepatic cell differentiation. Hepatology (2018) 67:313-327.


  1. Milosevic TV, Payen VL, Sonveaux P, Muccioli GG, Tulkens PM, Van Bambeke. Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically-relevant Concentrations in cultured Human HL-60 promyelocytes and THP-1 monocytes. Antimicrob Agents Chemother. (2017) pii: AAC.01599-17.

  2. Leonard C, Conrard L, Guthmann M, Pollet H, Carquin M, Vermylen C, Gailly P, Van Der Smissen P, Mingeot-Leclercq MP, Tyteca D. Contribution of plasma membrane lipid domains to red blood cell (re)shaping. Sci Rep. (2017) 7(1):4264.

  3. Coomans de Brachène A, Dif N, de Rocca Serra A, Bonnineau C, Velghe AI, Larondelle Y, Tyteca D, Demoulin JB. PDGF-induced fibroblast growth requires monounsaturated fatty acid production by stearoyl-CoA desaturase. FEBS Open Bio. (2017) 7(3):414-423.

  4. Bulanova EA, Koudan EV, Degosserie J, Heymans C, Pereira FD, Parfenov VA, Sun Yi, Wang Qi, Akhmedova SA, Sergeeva NS, Frank GA, Khesuani YD, Pierreux CE, Mironov VA. Bioprinting of functional and vascularized mouse thyroid gland construct. Biomaterials (2017) 9:034105.


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