Mar

10

Cellular plasticity in pancreatic cancer

Thursday, March 10, 2016, from 12:00 PM to 1:00 PM

Selected publications:

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.
Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT.
Nat Med. 2015 Oct;21(10):1163-71. doi: 10.1038/nm.3952. Epub 2015 Sep 21.

EGF receptor is required for KRAS-induced pancreatic tumorigenesis.
Ardito CM, Grüner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC, Siveke JT
Cancer Cell. 2012 Sep 11;22(3):304-17. doi: 10.1016/j.ccr.2012.07.024.

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma.
Mazur PK, Einwächter H, Lee M, Sipos B, Nakhai H, Rad R, Zimber-Strobl U, Strobl LJ, Radtke F, Klöppel G, Schmid RM, Siveke JT.
Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13438-43. doi: 10.1073/pnas.1002423107. Epub 2010 Jul 12.

Notch signaling is required for exocrine regeneration after acute pancreatitis.
Siveke JT, Lubeseder-Martellato C, Lee M, Mazur PK, Nakhai H, Radtke F, Schmid RM.
Gastroenterology. 2008 Feb;134(2):544-55. doi: 10.1053/j.gastro.2007.11.003. Epub 2007 Nov 4.

Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.
Siveke JT, Einwächter H, Sipos B, Lubeseder-Martellato C, Klöppel G, Schmid RM.
Cancer Cell. 2007 Sep;12(3):266-79.

Lecturer

Jens SIVEKE - Division of Translational Solid Tumor Oncology, DKFZ, University Hospital Essen, GERMANY
Jacquemin

Location

de Visscher Auditorium
Avenue Hippocrate 74 (Ground Floor)
1200 Brussels
Belgium