De Duve Institute


Complete publication list (Pubmed search) :

>> Link (Pierre Courtoy)

>> Link (Christophe Pierreux)

Representative publications :

D'auria L, Van der Smissen P, Bruyneel F, Courtoy PJ, Tyteca D.
Segregation of fluorescent membrane lipids into distinct micrometric domains: evidence for phase compartmentation of natural lipids?
PLoS One. 2011 Feb 28;6(2):e17021.PMID: 21386970

Medts T, de Diesbach P, Cominelli A, N'Kuli F, Tyteca D, Courtoy PJ.
Acute ligand-independent Src activation mimics low EGF-induced EGFR surface signalling and redistribution into recycling endosomes.
Exp Cell Res. 2010 Nov 15;316(19):3239-53. Epub 2010 Sep 9. Erratum in: Exp Cell Res. 2011 Jul 15;317(12):1785. PMID: 20832399

Tyteca D, D'Auria L, Der Smissen PV, Medts T, Carpentier S, Monbaliu JC, de Diesbach P, Courtoy PJ.
Three unrelated sphingomyelin analogs spontaneously cluster into plasma membrane micrometric domains.
Biochim Biophys Acta. 2010 May;1798(5):909-27. Epub 2010 Feb 1.PMID: 20123084

Pierreux CE, Cordi S, Hick A-C, Achouri Y, Ruiz de Almodovar C, Prévot P-P, Courtoy PJ, Carmeliet P, Lemaigre FP.
Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas.
Dev Biol 2010; 347:216-227

Hick A-C, van Eyll JM, Cordi S, Forez C, Passante L, Kohara H, Nagasawa T, Vanderhaeghen P, Courtoy PJ, Rousseau GG, Lemaigre FP, Pierreux CE.
Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1.
BMC Dev Biol 2009; 9:66.

de Diesbach Ph, Medts Th, Carpentier S, D’Auria L, Van Der Smissen P, Platek A, Mettlen M, Caplanusi A, van den Hove MF, Tyteca D, Courtoy PJ.
Differential membrane domain recruitment of Src specifies its downstream signalling (*, equal senior authors).
Exp Cell Res 2008, 314: 1465-79.

van den Hove MF, Croizet-Berger K, Tyteca D, Selvais C, de Diesbach Ph, Courtoy PJ.
TSH activates GDP/GTP exchange on the rate-limiting endocytic catalyst, Rab5a, in human thyrocytes in vivo and in vitro.
J Clin Endocrinol Metab. 2007, 92: 2803-10.

Platek A, Vassilev VS, de Diesbach Ph, Tyteca D, Mettlen M, Courtoy PJ.
Constitutive diffuse activation of phosphoinositide 3-kinase at the plasma membrane by v-Src suppresses the chemotactic response to PDGF by abrogating the polarity of PDGF receptor signalling.
Exp Cell Res. 2007, 313: 1090-105.

Nielsen R*, Courtoy PJ*, Jacobsen C, Dom G, Rezende-Lima W, Jadot M, Willnow TE, Devuyst O, Christensen EI.
Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells (*, equal first authors).
Proc Natl Acad Sci USA. 2007, 104: 5407-12.

Mettlen M, Platek A, Van Der Smissen P, Carpentier S, Amyere M, Lanzetti L, de Diesbach Ph, Tyteca D, Courtoy PJ.
Src triggers circular ruffling and macropinocytosis at the apical surface of polarized MDCK cells.
Traffic. 2006, 7: 589-603.

Christensen EI, Devuyst O, Dom G, Nielsen R, Van Der Smissen P, Verroust P, Leruth M, Guggino WB, Courtoy PJ.
Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules.
Proc Natl Acad Sci USA. 2003, 100: 8472-7.

Croizet-Berger K, Daumerie C, Couvreur M, Courtoy PJ, van den Hove MF.
The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production.
Proc Natl Acad Sci USA. 2002, 99: 8277-82.

Coppens I, Courtoy PJ.
The adaptative mechanisms of Trypanosoma brucei for sterol homeostasis in its different life-cycle environments.
Annu Rev Microbiol. 2000, 54: 129-56.

Amyere M, Payrastre B, Krause U, Van Der Smissen P, Veithen A, Courtoy PJ.
Constitutive macropinocytosis in oncogene-transformed fibroblasts depends on sequential permanent activation of phosphoinositide 3-kinase and phospholipase C.
Mol Biol Cell. 2000, 11: 3453-67.

Cupers P, Veithen A, Kiss A, Baudhuin P, Courtoy PJ.
Clathrin polymerization is not required for bulk-phase endocytosis in rat fetal fibroblasts.
J Cell Biol. 1994, 127: 725-35.