Involved group members: Miikka Vikkula, Pascal Brouillard, Daniel Manicourt
We try to identify the gene(s) responsible for the Ehlers-Danlos syndrome (EDS), hypermobility type, an under-recognized and yet relatively frequent condition. The syndrome has no cure and no distinctive biochemical collagen findings. Because of their excessive range of movement, joints are prone to joint dislocation and subluxations. The syndrome is a common cause of severe, early and multifocal osteoarthritis. Other clinical manifestations include chronic pain, easy bruising, functional bowel disorders, autonomic dysfunction and aortic root dilatation.