2. Endometrial xenografts & abnormal uterine bleeding
Metrorrhagia, i.e. abnormal endometrial bleeding, occurs spontaneously in many women without obvious organic lesions and is more frequent in patients on long-term progesterone contraception. In both conditions, we found that metrorrhagia is associated with menstrual-like stromal breakdown, particularly in foci containing low levels of ovarian steroids receptors, correlating with increased expression and activity of several MMPs. We currently develop endometrial xenografts in immunodeficient mice. This new experimental model should enable us to inhibit in vivo the activity of MMPs so as to directly address their role in physiological and abnormal endometrial bleeding, endometrial angiogenesis and vessel maturation through pericyte recruitment.
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