Control of cell function by protein phosphorylation
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Group Leader Mark Rider Contact Mark Rider de Duve Institute and Université catholique de Louvain PHOS - B1.74.02, Avenue Hippocrate 75, B-1200 Brussels phone: 32 (0)2 764 75 76 (Louis Hue); 32 (0)2 764 74 85 (Mark Rider) fax: 32 (0)2 764 75 07 e-mail: Mark Rider Group members > |
Research topics
Our group focuses on the control of cell function by reversible phosphorylation of proteins. Our main interests are the AMP-activated protein kinase (AMPK) and insulin signalling cascades. We also analyze protein covalent modification and differential protein expression by electrospray ionization (ESI) mass spectrometry (MS).
1. AMPK: We are currently engaged in the identification of new downstream targets of AMPK, and in the study of control by AMPK of (i) cell architecture, (ii) glycogen metabolism, (iii) ion transport, (iv) glucose transport and (v) adaptation to metabolic stress.
2. Insulin signalling: We are evaluating the role of insulin-stimulated protein kinases in controlling glucose uptake and glycolysis in the heart.
3. Mass spectrometry: On-line capillary 2D-LC-MS is being used for phosphorylation site identification and for the quantification of differential protein expression by gel-free proteomics.
