De Duve Institute


Cancer Immunology

Human Tumor Immunology

Pierre Coulie, Sophie Lucas
Vaccination of cancer patients with defined tumor antigens recognized by T lymphocytes is followed by objective tumor regression in a minority of patients. Our goal is to understand the mechanisms of these tumor regressions and the reasons for their rarity

Genetic & Epigenetic Alterations in Eukaryotic Genomes

Anabelle Decottignies, Charles De Smet
Genetic alterations : DNA damage repair and telomere maintenance mechanisms Epigenetic alterations : DNA methylation in cancer and development

Tumor Immunology & Antigen Processing

Benoît Van den Eynde, Etienne De Plaen
Building up on the molecular definition of tumor antigens recognized by T cells, our group mainly focuses on two aspects of tumor immunology, namely the processing of tumor antigens and the study of animal models to optimize cancer immunotherapy and evaluate tumor resistance mechanisms.

Regulation of T Lymphocyte Function in Tumors

Pierre van der Bruggen
Human tumor antigens recognized by T lymphocytes
T cell response of cancer patients Anergy of human CD8 T lymphocytes

Therapeutic Vaccination & Tumor Expression Profiling

Nicolas Van Baren
Therapeutic vaccination with MAGE tumor antigens
Expression profiling of tumor samples from vaccinated patients